polymer-congress-2018-scientifictracks

Polymer Congress 2018

Polymer Sciences

ISSN: 2471-9935

Page 28

June 04-05, 2018

London, UK

Edition of International Conference on

Polymer Science and

Technology

ecent progress in supramolecular chemistry leads to

unparalleled control over the composition and shape

factor of colloidal systems. Among them, the design of

hollow capsules is a new expanding area of physical-chemical

research. Herein, we report on the preparation of ultra-

low sized (<100 nm in diameter) biodegradable polymeric

capsules for potential applications as nanocontainers in

antibiotic therapy. Hollow nanospheres based on the chitosan/

poly (acrylic acid) pair are elaborated via (i) the layer-by-layer

technique using gold nanoparticles (20 and 60 nm in size) as

sacrificial templates, (ii) loading with amoxicillin, a betalactam

antibiotic, and (iii) removal of the gold core via cyanide-

assisted hydrolysis. Size, dispersity and concentration of the

resulting nanocapsules are easily fixed by the nanoparticle

templates, while wall thickness is controlled by the number of

polyelectrolyte bilayers. Electrostatic interactions between the

protonated amine groups of chitosan and the carboxyl groups

of poly(acrylic acid) act as the driving attraction force allowing

easy and fast design of robust and well-ordered multilayer

films. Successful hydrolysis of the gold core is evidenced by

time-dependent monitoring of the gold spectroscopic signature

(absorbance at 519 nm and 539 nm for the gold nanoparticles

with 20 and 60 nm, respectively). Crosslinked capsules are

also prepared through crosslinking of the chitosan chains

with gluteraldehyde. Chitosan-based nanocapsules are finally

evidenced to be promising drug delivery vehicles of amoxicillin

trihydrate with tuneable properties such as entrapment

efficiency in the range of 62-75% and 3.5-5.5% concerning the

drug loading. The drug-loading content was up to 5%.

Recent Publications

1. Peyratout C S and Dahne L (2004) Tailor-made

polyelectrolyte microcapsules: from multilayers to

smart containers. Angewandte Chemie. 43:3762-

3783.

2. Borges JOandMano J F (2014) Molecular interactions

driving the layer-by-layer assembly of multilayers.

Chemical reviews. 114:8883-8942.

3. Nguyen T T T et al. (2017) From the functionalization

of polyelectrolytes to the development of a versatile

approach to polyelectrolyte multilayer films with

enhanced stability. Journal of Materials Chemistry A.

5(46):24472-24483. Doi:10.1039/C7TA06855G

4. Belbekhouche S et al. (2018) Glucose-sensitive

polyelectrolyte microcapsules based on (alginate/

chitosan) pair. Carbohydrate Polymers. 184:144-153.

5. Jiang H X, Ding Y, Chen Q and Yang C (2004)

Core‐template‐free strategy for preparing hollow

nanospheres. Advanced Materials. 16:933-937.

Biography

Sabrina Belbekhouche is an Associate Professor (East Paris Institute of

Chemistry And Materials Science/ University of Paris, France). Her core

expertise is in polymer science, macromolecular assembly and surface

modification. This includes the polymer synthesis; the study of the physi-

cal chemistry of surfaces/interfaces; and the use of controlled assembly

at the sub-micrometer scale (nanoparticle, nanocapsule.) as well as stim-

uli-responsive systems. Current applications of her research are mainly for

biological application.

belbekhouche@icmpe.cnrs.fr

Promising tailor made nanocapsules based on biopolymer for

antibiotic therapy

Sabrina Belbekhouche, Ones Mansour

and

Benjamin Carbonnier

ICMPE (UMR7182), France

Sabrina Belbekhouche et al., Polym Sci 2018, Volume 4

DOI: 10.4172/2471-9935-C2-011

Figure 1:

Schematic illustration of hollownanocapsule elaboration by the polyelectrolyte

layer by layer self-assembly strategy. (NP: nanoparticle).

hollow