Antibacterial activity of various extracts was studied against gram positive bacteria like, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and gram negative bacteria like E.coli and Klebsiella pneumonia. These studies revealed that the methanolic extract of safflower florets showed varying degree of antibacterial activities ex-cept aqueous extract may be due to the presence of secondary metabolites, the highest zone of inhibition with 21 mm diameter in bacillus whereas lowest 13 mm diameter in Pseudomonas.
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