Texas Biomedical Research Institute
"Dr. Sandeep Gupta, MD, MSc. has more than 14 years of research experience in the field of immunology, Fc receptor biology, antibody trafficking and signaling and over 6 years of experience in the field of HIV transmission, mucosal immunology and HIV/AIDS vaccine research. After obtaining his MD from Romania, Dr. Gupta completed his graduate and postdoctoral studies at the University of Toronto, Canada. He worked as an Assistant project Scientist at the University of California, Irvine, before joining Texas Biomedical Research Institute as a Staff Scientist.
At his current position, Dr. Gupta is a co-core leader of primate studies on a $23 million international multi-institute collaborative HIV/AIDS vaccine development project titled "Defense-in-depth against mucosal HIV clade C invasion?, funded by the National Institutes of Health. In addition, I he conducting pre-clinical vaccine trials on rhesus macaque models testing novel HIV/AIDS vaccine candidates, including finding a cure for "elite controllers" of HIV/AIDS infection (funded by NIH) and those using a virosome-based approaches (funded by Bill and Melinda Gates Foundation). Dr. Gupta has created a simian-human immunodeficiency virus (SHIV-E) in collaboration with The US Military HIV Research Program (MHRP), funded by the Henry M Jackson (HMJ) Foundation for the Advancement of Military Medicine and is in the process of identifying the first HIV target cell in infants after mother to child transmission through breast milk (funded by the NIDCR).
During his tenure as an Assistant Project Scientist at the University of California, Irvine, Dr. Gupta developed a new model of sexual transmission of HIV called ?transcytosis? that uses the neonatal Fc Receptor and have conducted passive vaccination in rhesus monkeys highlighting the protective role of IgA in AIDS virus transmission by transcytosis inhibition. As a Postdoctoral Fellow previously at the University of Toronto, Dr. Gupta had contributed significantly to the development of anti-diabetic Fc fusion proteins (GLP-1/hIgG2Fc and Exendin-4/IgG2Fc) has studied the role of Fc Gamma Receptors in chronic inflammation and autoimmune diseases.
Dr. Gupta?s primary focus has been mucosal immunology, HIV transmission biology and AIDS vaccine research. Dr. Gupta has several publications in the field of immunology and AIDS research and serves as editor and reviewer to many journals in these fields."