Filippo M. Perna
Assistant Professor of Organic Chemistry, University of Bari Aldo Moro, Italy.
Filippo M. Perna received his degree in Chemistry and Pharmaceutical Technology in 1999 from the University of Bari under the supervision of Prof F. Naso. In 2003 he was at University of Oviedo in Spain working on a research project Conjugated additions of lithiated haloalkyl oxazolines and oxiranes to alpha,beta-unsaturated Fischer carbene complexes in the group of Prof J. Barluenga . In March 2004 he received his PhD in ?Applied Chemical and Enzymatic Synthesis? under Prof S. Florio?s supervision. Up to 2006, he worked at project research FIRB: Design, preparation and pharmacological and biological evaluation of new organic molecules as potential new drugs in the treatment of common and rare diseases. In July 2006 he became assistant professor in organic chemistry at University of Bari and joined Prof S. Florio and Prof. V. Capriati research group working in the field of organometallic chemistry.
- Functionalized Organolithiums: elucidation of the structure-reactivity relationship and of their dynamic behavior by means of a synergistic combination of ab initio calculations, X-ray analysis, and multinuclear magnetic resonance investigations; mechanistic and kinetics studies of enantiomerization of chiral organolithiums; synthesis of enantiomerically or diastereomerically enriched organolithiums and their stereospecific functionalization by interception with electrophiles; optimization of organometallic reactions by in-situ IR and NMR monitoring of the reactive intermediates involved; asymmetric synthesis of (new) heterocycles, natural product analogues, and target molecules of pharmaceutical and biological interest; the discovery of new reactions.
- Organoboron and organofluorine chemistry.
- Cross-coupling reactions.
- Strained cycles in organic synthesis.
- Preparation of key optically active buiding blocks as starting materials for asymmetric synthesis by means of biocatalytic processes employing enzymes or whole cells microorganisms.
- The development of new sustainable chemical processes using unconventional solvents (e.g., water and deep eutectic solvents).
- Application of lithium chemistry in medicine and in the field of material sciences.