euro-infectious-diseases-histopathology-2018-posters

Volume 4

Journal of Infectious Diseases and Treatment

ISSN: 2472-1093

Page 51

Euro Infectious Diseases 2018 &

Histopathology 2018

September 27-29, 2018

JOINT EVENT

September 27-29, 2018 Rome, Italy

International Conference on

Histopathology & Cytopathology

Euro-Global Conference on

Infectious Diseases

Direct evidence of viral infection and mitochondrial alterations in the brain of fetuses at high risk for

schizophrenia

Segundo Mesa Castillo

Havana Psychiatric Hospital, Cuba

Background:

There is increasing evidences that favor the prenatal beginning of schizophrenia. These evidences point toward

intra-uterine environmental factors that act specifically during the second pregnancy trimester producing a direct damage of

the brain of the fetus. The current available technology doesn't allow observing what is happening at cellular level since the

human brain is not exposed to a direct analysis in that stage of the life in subjects at high risk of developing schizophrenia.

Methods:

In 1977 we began a direct electron microscopic research of the brain of fetuses at high risk from schizophrenic

mothers in order to finding differences at cellular level in relation to controls.

Results:

In these studies we have observed within the nuclei of neurons the presence of complete and incomplete viral particles

that reacted in positive form with antibodies to herpes simplex hominis type I [HSV1] virus, and mitochondria alterations.

Conclusion:

The importance of these findings can have practical applications in the prevention of the illness keeping in mind

its direct relation to the aetiology and physiopathology of schizophrenia. A study of the gametes or the amniotic fluid cells in

women at risk of having a schizophrenic offspring is considered. Of being observed the same alterations that those observed

previously in the cells of the brain of the studied foetuses, it would intend to these women in risk of having a schizophrenia

descendant, previous information of the results, the voluntary medical interruption of the pregnancy or an early anti HSV1

viral treatment as preventive measure of the later development of the illness.

J Infec Dis Treat 2018, Volume 4

DOI: 10.21767/2472-1093-C1-003