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Volume 4
Journal of Infectious Diseases and Treatment
ISSN: 2472-1093
Page 49
Euro Infectious Diseases 2018 &
Histopathology 2018
September 27-29, 2018
&
JOINT EVENT
September 27-29, 2018 Rome, Italy
5
th
International Conference on
Histopathology & Cytopathology
10
th
Euro-Global Conference on
Infectious Diseases
Interleukin-36α expression in vitiligo skin lesions and its correlation with disease pattern, activity and
severity
Sahar F Mansour
1
, Mona A Atwa
1
, Lina M Atef
1
and
Rasha Mohamed Ibrahim Mohamed
2
1
Suez Canal University, Egypt
2
Ismailia General Hospital, Egypt
V
itiligo is an acquired multivariate disease, that results in gradual selective degeneration of cells that produce pigmentation
in the skin. There is still an ongoing debate about what causes damage to melanin cells and their disappearance from
infected skin. Many theories to explain the pathogenesis of vitiligo exist. Recently, one of the autoimmune pathogens theory
has been suggested. Interleukin (IL)-36α belongs to interleukin (IL)36-cytokine family, that have a role in organizing non
specific as well as acquired immune responses. It is proved that interleukin 36 in many skin disorders, especially autoimmune
ones including for example psoriasis. The study will be conducted in an attempt to evaluate interleukin 36α expression using
IHC in skin (lesional and non lesional) punch biopsy from vitiligo patients and detect the correlation between interleukin 36α
expression with demographic (age, gender,..) and clinical parameters (disease pattern, activity and severity).
Biography
Sahar F Mansour has completed her MD from Suez Canal University, Ismailia, Egypt. She is an Assistant Professor of the Pathology Department of Faculty of
Medicine, a premier research organization. She has published more than 10 papers in reputed journals.
sfansour36@gmail.comSahar F Mansour et al., J Infec Dis Treat 2018, Volume 4
DOI: 10.21767/2472-1093-C1-003