euro-infectious-diseases-histopathology-2018-posters

Volume 4

Journal of Infectious Diseases and Treatment

ISSN: 2472-1093

Page 56

Euro Infectious Diseases 2018 &

Histopathology 2018

September 27-29, 2018

JOINT EVENT

September 27-29, 2018 Rome, Italy

International Conference on

Histopathology & Cytopathology

Euro-Global Conference on

Infectious Diseases

Preoperative nasopharyngeal decolonization using mupirocin and chlorhexidine in preventing surgical

site infection: Ameta-analysis

Buaron Michelle Jane A, Semeniano Russel, Ombao Genevie

and

Y U Catherine

St. Luke’s Medical Center, Philippines

Background:

Preoperative decolonization is a preventive strategy for surgical site infection. Clinical trials have been done to

prove or disprove the efficacy of decolonization in the prevention of surgical site infection. However, great heterogeneity in

results was noted in many published studies.

Objective:

We assessed whether preoperative decolonization reduces the risk of surgical site infection.

Method:

PubMed and Google free texts search terms: decolonization and surgical site infection inclusion criteria: >/=18

years old of either gender undergoing any surgery, may or may not screened for carriage of

S. aureus

; studies are randomized

controlled trial (RCT).

Results:

Using the random effects model, the computed summary statistic was 0.59 with CI 0.37-0.94 in favor of the

experimental treatment. However, due to substantial heterogeneity (Tau2 of 0.25 Chi2 30.34 and I2 of 84%), we cannot draw

definite conclusion from the meta-analysis. Subgroup analysis using both mupirocin nasal swab and chlorhexidine gargle were

used for preoperative decolonization, the summary statistic generated was 0.40 with 95% CI of 0.23-0.69, with no heterogeneity

(Tau2 of 0, Chi2 of 0.09 and I2 of 0.) and was noted to be in favor of the experimental treatment.

Conclusion:

Pre-operative decolonization using both mupirocin and chlorhexidine for preoperative decolonization showed

that it could significantly prevent surgical site infection.

J Infec Dis Treat 2018, Volume 4

DOI: 10.21767/2472-1093-C1-003