euro-infectious-diseases-histopathology-2018-posters

Volume 4

Journal of Infectious Diseases and Treatment

ISSN: 2472-1093

Page 60

Euro Infectious Diseases 2018 &

Histopathology 2018

September 27-29, 2018

JOINT EVENT

September 27-29, 2018 Rome, Italy

International Conference on

Histopathology & Cytopathology

Euro-Global Conference on

Infectious Diseases

Cytomegalovirus

infection and coronary artery disease: Asingle center serologic study in north-western

Iran

Zakieh Rostamzadeh, Nariman Sepehrvand

and

Zahra Shirmohammadi

Urmia University of Medical Sciences, Iran

Background:

The role of chronic

cytomegalovirus

(CMV) infection and inflammation in the pathogenesis of atherosclerosis

and coronary artery disease (CAD) is still not clear. In this study the aim is to investigate the seroprevalence of anti-CMV

antibodies and inflammatory markers in patients who were undergone diagnostic coronary angiography for clinical suspicion

of CAD.

Methods:

In this cross-sectional descriptive study, 181 patients were selected randomly among those who were referred for

diagnostic coronary angiography to the Seyyedoshohada Heart Hospital of Urmia, in the north-western region of Iran (Aug

2012- Dec 2013). Patients were categorized into either of CAD or non-CAD groups, based on their angiography findings. Anti-

CMV IgG and IgM antibodies were tested using the enzyme-linked immunosorbent assay (ELISA) method. Serum C-reactive

protein (CRP) was measured by a qualitative method (Aniston Kit).

Results:

A hundred and forty one patients (77.9%) had atheromatous plaques in their coronary arteries in angiography, and

in 40 cases (22.1%), coronary arteries were free of any plaque. Based on the ELISA results, 171 (99.4%), 21 (12.0%), and 112

(62.9%) cases were respectively seropositive for anti-CMV IgG, IgM, and CRP. 99.3% in the CAD group and 100% in the non-

CAD group were anti-CMV IgG positive. The rates for anti-CMV IgM seropositivity were 11.7% in CAD group versus 13.2% in

non-CAD group, p=0.78. Groups with and without angiographically-documented CAD, had no significant difference in terms

of their CRP seropositivity (64.7% vs. 56.4%, p=0.34).

Conclusion:

Regardless of having angiographically-proven CAD or not, almost all cases who referred for coronary angiography

in our study, had a previous exposure with CMV infection as determined by the presence of anti-CMV IgG antibodies in

serum. No association was observed between CMV infection and the presence of CAD, which could be justified with the high

rate of CMV-specific IgG antibody seropositivity.

J Infec Dis Treat 2018, Volume 4

DOI: 10.21767/2472-1093-C1-003