euro-infectious-diseases-histopathology-2018-posters

Volume 4

Journal of Infectious Diseases and Treatment

ISSN: 2472-1093

Page 66

Euro Infectious Diseases 2018 &

Histopathology 2018

September 27-29, 2018

JOINT EVENT

September 27-29, 2018 Rome, Italy

International Conference on

Histopathology & Cytopathology

Euro-Global Conference on

Infectious Diseases

Sepsis associations with HLA-DR and -DQ genes

Linda Bridina

and

Angelika Krumina

Riga Stradins University, Latvia

Aim:

Despite the extended laboratory and clinical study of sepsis, its diagnosis remains a clinical challenge. The initiation

of sepsis activates many different biochemical and immunological pathways, which is expressed with alterations of many

molecules on human tissues. The aim of this research was to investigate the genetically determined predisposition to developed

sepsis by analysis of distribution of human leukocyte antigen HLA class II genes. We summarize the evidence for a genetic

susceptibility to develop the sepsis and unfavorable outcome of sepsis. We consider the candidate genes are likely to be involved

in the pathogenesis of sepsis and based on genetic variability.

Method:

This was a single-center study at Pauls Stradins Clinical University Hospital in Latvia. The study group consisted of

patients (n=62) who had sepsis who were enrolled during an 8-month period. The immunogenetic part of the study was done

and 62 sepsis patient and control group, samples of 100 healthy individuals who were genotyped for HLA-DRB1; DQB1 and

DQA1 using RT-PCR with sequence-specific primers.

Results:

Summarized results shows that the alleles: DRB1*04:01 (OR=5.54; 95%CI=1.88-16.29; p=0.001); DRB1*07:01

(OR=19.03; 95%CI=2.37-152.82; p=0.001); DQA1*05:01 (OR=14.17; 95%CI=5.67-35.4; p<0.001); DQB1*02:01 (OR=50.00;

95%CI=2.90-861.81; p<0.001) were significantly increased in patients with sepsis compared to the control group patients.

Comparing these alleles who were significantly increased in patients with sepsis compared to the control group patients with

the most common final clinical diagnosis was pneumonia 66% (n=41).

Conclusion:

Undoubtedly, our preliminary data shows that development of sepsis can have association with opedelenny alleles

of genes HLA class II. These results have to be confirmed prospectively in a large population.

J Infec Dis Treat 2018, Volume 4

DOI: 10.21767/2472-1093-C1-003