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Volume 4
Journal of Infectious Diseases and Treatment
ISSN: 2472-1093
Page 67
Euro Infectious Diseases 2018 &
Histopathology 2018
September 27-29, 2018
&
JOINT EVENT
September 27-29, 2018 Rome, Italy
5
th
International Conference on
Histopathology & Cytopathology
10
th
Euro-Global Conference on
Infectious Diseases
Preclinical multimodel imaging of bacterial infections and the potential for clinical translation
Kevin P Francis
1, 2, 3
1
PerkinElmer, USA
2
University of California, Los Angeles, USA
3
Texas A&M University, USA
E
ach year more than 70 billion standard units of antibiotic are prescribed to treat bacterial infections worldwide. In addition,
at least 63,000 tons of antibiotics are consumed by livestock for growth promotion and disease prevention. The result of
this overuse of antibiotics is a spiraling increase in resistance. In the United States and Europe, antibiotic resistant bacteria
are responsible for more than 4 million infections and approximately 50,000 deaths annually. In addition, bacteria such as
methicillin-resistant Staphylococcus aureus (MRSA) have increased in prevalence in hospitals over the last three decades.
Such bacteria are particularly problematic in postoperative infections, exacerbating treatment through the development of
biofilms, especially on medical implants which are extremely hard to treat without removal and replacement of the device.
This presentation will show how non-invasive preclinical imaging (optical, PET and CT) is being used to better understand the
establishment and development of bacterial infections in a number of defined animal disease models of bacterial infections,
and how best to treat them. In particular, data will be shown as to how preclinical imaging can be used to monitor biofilms on
orthopedic implants and how this technology might be translated into the clinic.
kevin.francis@perkinelmer.comJ Infec Dis Treat 2018, Volume 4
DOI: 10.21767/2472-1093-C1-003