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Page 46
Biochemistry & Molecular Biology Journal
ISSN: 2471-8084
Internat i ona l Conference on
Biotechnology, Biomarkers
& Systems Biology
M a r c h 0 4 - 0 5 , 2 0 1 9
Am s t e r d a m , N e t h e r l a n d s
Biotechnology, Biomarkers & Systems Biology 2019
Amal Akour et al., Biochem Mol biol J 2019, Volume:5
DOI: 10.21767/2471-8084-C1-024
Background:
Urinary albumin excretion has been used as a marker for diabetic
nephropathy. Megalin is a 600-kDa protein expressed in renal proximal tubular
cells and it is involved in the reabsorption of vitamin D binding protein. Recently,
urinary megalin excretion has been evaluated as a potential urinary marker of
nephropathy. The aim of this study is to evaluate the correlation between the
urinary megalin and serum vitamin D levels.
Methods:
This was a pre-post study in patients with type 2 diabetes mellitus
to examine the effect of 6-month vitamin D on diabetic nephropathy. Results.
Urinary megalin was positively associated with SBP (r=0.218, p=0.04) but
negatively with GFR (r=-0.16, p=0.023). In addition, when patients were divided
according to urinary megalin cutoff point level that qualifies failure, urinary
albumin, and TGs were higher in the "high-megalin" group, compared to those
with “low-megalin” group. Glycosylated hemoglobin (HbA1c) was statistically
and significantly higher in the high-megalin group. A stepwise forward logistic
regression which was adjusted for SBP, FPG, and calcium levels showed that
there is a significant inverse association between vitamin D levels and megalin
levels in urine (OR= 0.281, p-value=0.047). Conclusion. Urinary megalin is
a potential marker for diabetic nephropathy is correlated with the extent of
vitamin D. Of the 209 patients, 63 patients who had vitamin D deficiency were
given supplements of vitamin D. There was a significant improvement in kidney
function (
increase
in GFR and
decrease
in ACR), with concomitant decrease in
urinary megalin and increase in vitamin D3. The decrease in megalin was more
pronounced than ACR, which indicates that megalin is more sensitive than ACR
to changes in renal function over a shorter period of time.
Biography
Amal Akour received her Bachelor of Pharmacy from the
University of Jordan in 2007 and had completed her Ph.D.
in 2012 from Virginia Commonwealth University, Virginia,
USA. She is currently working as an Associate Professor
of Pharmacotherapy at the School of Pharmacy, University
of Jordan, Amman, Jordan. Also, she had been working as
Assistant Dean for Hospital affairs and Pharm.D. program in the
same institute from September 2015 till September 2017. She
is an active member of academic and scientific committees
as well as social organizations. She is leading active research
group evaluating markers of diabetes progression with the
attempt of finding novel progression/therapeutic markers for
this epidemic. She has a number of publications in reputed
ISI Journals. In addition, she has volunteered to serve her
community by providing free health-awareness lectures,
supervising free medical days and reviewing publications.
a.akour@ju.edu.joUrinary megalin as a potential marker for diabetic
nephropathy: correlation with vitamin D levels
Amal Akour
1
, Violet Kasabri
1
, Nailya Bulatova
1
and Ali Altae
2
1
The University of Jordan, Jordan
2
Al-Safwa University, Iraq