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Biochemistry & Molecular Biology Journal
ISSN: 2471-8084
Internat i ona l Conference on
Biotechnology, Biomarkers
& Systems Biology
M a r c h 0 4 - 0 5 , 2 0 1 9
Am s t e r d a m , N e t h e r l a n d s
Biotechnology, Biomarkers & Systems Biology 2019
Voxel-wise analysis is a class of modern methods of image processing in the medical field with increased popularity. It has
replaced manual region of interest (ROI) analysis and has provided tools to make statistical inferences at voxel level. Voxel-based
morphometry (VBM) is another popular inter individual voxel-based image analysis method that measures differences in local
concentrations of brain tissue, through a voxel-wise statistical comparison of multiple tissue density maps. These maps are
generated by the normalization of high-resolution structural images (i.e. 3-D T1-W spoiled gradient-echo) and their segmentation
to grey matter, white matter and cerebrospinal fluid. Usually VBM is used to compare tissue density maps between two groups and
detect regional brain atrophy or hypertrophy. The structural impact of many neuropsychological disorders or birth complications
has been studied with VBM in children. Moreover VBM has allowed monitoring of childhood brain development. Combined with
advanced normalization techniques it has allowed study of population-related effects. The wide use of standard atlases has
facilitated the next level of application, which is voxel based meta-analysis comparing regional effects across studies, providing
quantitative summaries with good control of statistical error. Future technological advances are expected to increase the clinical
uptake; to improve the impact of quantitative techniques on clinical practice; and to improve our understanding of complex
pathological processes. Likely to be an important biomarker in future drug trials to assess treatment effects at the group level.
dhananjayakvn@gmail.comVoxel based analysis of paediatric brain and its
clinical application: biomarker tool for future
drug trials
Dhananjaya Kotebagilu Narayana Vamyanmane
Manipal University, India
Biochem Mol biol J 2019, Volume:5
DOI: 10.21767/2471-8084-C1-024