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Page 58
Biochemistry & Molecular Biology Journal
ISSN: 2471-8084
Internat i ona l Conference on
Biotechnology, Biomarkers
& Systems Biology
M a r c h 0 4 - 0 5 , 2 0 1 9
Am s t e r d a m , N e t h e r l a n d s
Biotechnology, Biomarkers & Systems Biology 2019
S
uper enhancers, the genome regions including large clusters of transcriptional enhancers, are shown to specifically regulate
the genes involved in cell identity and disease, including oncogenes, and to play critical roles in the development and
progression of cancer. Recent studies have attempted to elucidate the function of super enhancers by means of microRNAs.
Although the functional outcomes of microRNAs have become clearer, the pathways that regulate the expressions of microRNAs
remain unclear. In this study, we hypothesized that the inhibition of cell proliferation induced by the disruption of the -related super
enhancer may be associated with microRNAs. As a result, it was demonstrated that the over-expression of miR-1301 induced
by the disruption of the -related super enhancer leads to a significant inhibition of proliferation in HepG2 cells. Moreover, it was
demonstrated that the -related super enhancer propagates the anti-proliferative and pro-apoptotic effects which are mediated, at
least in part, by the induction of p
21
and p
53
in a p
53
-dependent manner.
rkc19810303@163.com 15124579835@163.comThe Klf6-related super enhancer modulates cell
proliferation via miR-1301 in human hepatoma
(HepG2) cells
KumChol Ri
1, 2
, Chol Kim
2
and SunIl Choe
1
KumChol Ri
1, 2
, Chol Kim2 and SunIl Choe1
1
Harbin Institute of Technology, China
2
University of Science, Democratic People’s Republic of Korea
Biochem Mol biol J 2019, Volume:5
DOI: 10.21767/2471-8084-C1-024