Nanoenzyme-Reinforced injectable hydrogel accelerates oxidative diabetic wound healing through timed-release of exosome and fibroblast growth factor

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Abstract

The treatment of diabetic wounds remains one of the major challenges in clinical practice, due to the multiple drug-resistant bacterial infections, angiopathy, and oxidative damage to the microenvironment. Herein, we sought to introduce a novel in-situ injectable HA@MnO2 hydrogel to accelerate the diabetic wound healing. Through the convenient injection, this hydrogel can form a protective dressing covering the wound to provide rapid haemostasis and long-term antibacterial. Meanwhile, the MnO2/ e-PL nanosheet catalyze the overexpressed H2O2 in wound to convert to O2, so that eliminating the harmful effect of H2O2 and providing enough O2 for wound healing. Moreover, the following releasing of M2-derived Exosome (M2 Exo) and FGF-2 growth factor constantly simulate the angiogenesis and epithelization, respectively. The in vivo and in vitro results determined an accelerated diabetic wound healing using HA@MnO2 hydrogel, which representing a versatile strategy for repairing a wide range of diabetic tissue damages.

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