Abstract

Simultaneous Determination of aceclofenac and thiocolchicoside by reverse phase high performance liquid chromatography form bulk drug and pharmaceutical dosage form

A simple, economical and accurate high performance liquid chromatography method is described for simultaneous determination of aceclofenac and thiocolchicoside from combined dosage form i.e. tablets. The separation of drug was achieved on Intersil ODS 3V C18 (150 x 4.6 mm i.d.) with 5 μ particle size, column. It showed most favorable chromatographic pattern over the other columns. The mobile phase consisted of a mixture of buffer and acetonitrile (66:34 %( v/v)). The buffer was 0.01 M sodium dihydrogen phosphate solution and 1 ml triethyl amine. The detection was carried out at wavelength 263 nm. The mixture of buffer and acetonitrile (66:34% v/v) was used as a diluent. The method was validated for system suitability, linearity, accuracy, precision, robustness, stability of sample solution. The method has been successfully used to analyze aceclofenac and thiocolchicoside from combined dosage form i.e. tablets.


Author(s): Rajan V. Rele* and Swapnil A. Sawant

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