Medicinal plants have long enjoyed their reputation as healing agents. The Fagonia species belong to the family Zygophyllaceae which has long been widely studied with respect to its medicinal importance. This study was focused on antimicrobial potential of Fagonia species. The disc diffusion method was used to assess antimicrobial potency of the methanolic, protein and buffer extracts of Fagonia species: F. arabica and F. indica. It was observed that all microbial strains were sensitive (>7 mm inhibition zone) to both the plant species with the exception of Staphylococcus aureus and Ganoderma lucidum and that F. arabica displayed a higher antimicrobial effect than F. indica.The current study show that Fagonia protein extract had a high antimicrobial activity because of proteins or peptides. The results of this study hint at the potential of Fagonia species as sources of healing and medicinal agents.