Abstract

Hyperglycemia and hyperlipidemia mitigating impact of Catharanthus roseus (Sadabahar) leaves aqueous extract on type2 diabetes mellitus subjects

Type 2 diabetes is increasing at a very high rate especially in developing countries. This disease is co associated with several complications, CVD is one of them. With the disturbing rise in the prevalence of this metabolic disease and associated healthcare cost, interest in alternative or complementary therapies has been grown. Catharanthus roseus has been used for centuries to treat a variety of ailments and was a favorite ingredient of magical charms in the middle ages. To assess the efficacy of Catharanthus roseus leaves aqueous extracts (75 mg/day) on diabetes and lipid profile and to observe whether the sustained use of Catharanthus roseus aqueous leaves extract produces any side effects. 60 diabetic subjects were divided into two groups (In Group A and B, n= 30 per group) and supplemented with Catharanthus roseus water extract for 30 days .The results were compared with control group by measuring blood glucose levels and lipid profile. On analyzing the fasting blood glucose level, post prandial blood glucose level, glycated Hb and total cholesterol, total triglyceride, Low density lipoprotein-Cholesterol (LDL-C), High density lipoprotein-Cholesterol (HDL-C), Very low density lipoprotein-Cholesterol (VLDL-C), a significant reduction was observed except High density lipoprotein-Cholesterol was found to be non significant in this study. No side effects of the sustained use of Catharanthus roseus aqueous leaves extract were seen. Result suggest that Catharanthus roseus can be used as prophylactic agent in the progressively abnormalities related to the diabetes.


Author(s): Gita Bisla, Shailza Choudhary, Ekta Singh and Vijeta Chaudhary

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