In Ethiopia, the green bean (Phaseolus vulgaris L.) is a significant vegetable and a top priority crop. The countrywide productivity of the green bean is low, primarily due to poor soil fertility. According to the governmental soil database, the majority of the southwest Ethiopian soils are sulfur, phosphorus, and nitrogen deficient. However, a study on using two different types of green beans and NPS fertilizer rates. In order to ascertain the optimal rate of NPS fertilizer and varieties for Gambella in 2020, a field experiment was conducted. Treatments included four NPS fertilizer rates (0, 50, 100, and 150 kg ha-1) and green beans varieties (BC4.4 and Platia). The factorial design was used in a randomized complete block arrangement three times to set up the experiment. SAS software was used to collect and statistically analyze data on plant height, number of main branches, and number of pods per plant, total pod yield per hectare, marketable pod yield per hectare, above ground dry biomass, harvesting index, and pod protein content. The combined application of NPS and varieties had a substantial impact on plant height, the number of pods produced per plant, total pod yield, marketable pod yield, and above ground dry biomass, according to the results. The predominant effect of NPS fertilizer rates, however, was on the number of primary branches, harvesting index, and protein concentration of the pods. When the plots received the combined treatment of 150 kg ha-1 of NPS fertilizer with BC4.4 variety, the highest pod yield (3.43 ha-1) and marketable pod yield (2.72 tha-1) of green beans were attained. Therefore, based on the findings of the current study, farmers can gain extra advantages by applying 100 kg of NPS fertilizer along with the BC4.4 green bean variety, which produced the highest yield of marketable green beans.