Soil salinity is a major constraint in agriculture particularly in food production because it limits crop yield and restricts the use of land previously untreated. Wheat is grown in arid and semi-arid regions of the world. Reduced shoot growth by salt stress was higher in salt sensitive genotypes in relation to resistance to salt alone. When both genotypes were subjected to salt stress (150 mM NaCl) significant changes in leaf area and the osmotic pressure was found. However, salt stress caused an increase in superoxide dismutase, catalase and peroxidase in both genotypes. These increases induced by salt more salt resistant genotypes. Peroxidase activity was reduced by salt stress in saltsensitive genotypes and increased salt tolerant genotypes. WMB-1 held maximum and minimum weight AS-2000 to take salinity compared to control. In addition, the relationship between the activity of superoxide dismutase and catalase enzymes were higher in salt tolerant genotypes. Thus, our results are consistent with hypothesis that the efficacy of antioxidant enzyme system WMB genotype 1 can be considered as one of the factors responsible for resistance to salt stress. It is assumed that the ratio of superoxide dismutase and catalase enzyme activity can be used as a working hypothesis for the biochemical markers of salt tolerance of wheat.