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Anticlastogenic effect of Allium sativum extract against lead-induced necrosis in liver and kidney of albino rats

The anticlastogenic potential of Allium sativum aqueous extract was evaluated on lead-induced necrosis in liver and kidney tissues of albino rats in vivo. The rats were administered 2.5mg/kg lead acetate and 100mg/kg Allium sativum aqueous extract for a period of 4-weeks. The change in organ to body weight ratio of the treated rats as well as the pathological condition of the liver and kidney tissues were also assessed. The result showed that change in organ to body weight ratio of the animals fed with lead acetate was significant (P<0.05) when compared with control. Besides, the histopathological examination of liver and kidney tissues of rat fed with the clastogen alone indicates grossly necrotic or mutated cells, riddled with lesions of varying degrees. However, a slight modification was observed in tissues of animals fed with the extract which were fairly normal and well vascularized. Hence, Allium sativum could possibly offer protection against heavy metal-induced necrosis in liver and kidney tissues.

Author(s): Tugbobo OS, Ologunde CA and Orji EE

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