Anthelminitic activity of different extracts of prosopis cineraria (Linn) druce stem bark was evaluated against Indian earthworm. Various concentrations of the extracts were bioassayed for the determination of time of paralysis (p) and time of death (d) of the worm. Piperazine citrate at a concentration of 10 mg/ml has been used as reference standard. In our present study, the crude methanolic extract demonstrated paralysis and also caused death of worms especially at the higher concentration (50 mg/ml) compared to the standard, piperazine citrate. This study confirmed the use of plant stem barks as an anthelmintic agent.