A study on the effects of Moringa oleifera lam. pod extract on alloxan induced diabetic rats

The present study was designed to evaluate the effects of Moringa oleifera Lam. pods in the alloxan treated diabetic rats. The rats with body weight 200–250 g of either sex were selected for the study. Alloxan was given by single tailvein injection (60 mg kg–1). The alloxan treated rats showed significant increase in the blood glucose and impaired glucose tolerance. The metfornin and ethanolic extract of Moringa oleifera Lam. pod (MOP) was administered orally, once a day for 21-days. The blood glucose, oral glucose tolerance, body weight and biochemical parameters like SGOT, SGPT and creatinine was evaluated in alloxan induced diabetic rats for 21-days. The result of the study showed that decrease in blood glucose level by MOP and improvement in the glucose tolerance at the end of 21- days. The MOP also significantly reduced elevated SGPT, SGOT and creatinine in alloxan treated rats indicating reduction in the secondary complications in the diabetic rats. MOP also improves the body weight of alloxan treated rats. The result of study proved the hypoglycemic effects of MOP in alloxan treated diabetic rats. It may be due to the presence of flavonoids, which helps to speed up the natural healing process and may improve the glycemic control in diabetic rats.

Author(s): Une Hemant D.*, Shingane Pradip and Patave Tarannum R.

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