Department of Anatomy and Regenerative Biology, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.
|The Hedgehog (Hh) signaling pathway organizes pattern formation in a variety of embryonic tissues and functions post-embryonically in homeostatic processes. Hh pathway dysfunction thus can lead to embryonic pattern disruptions, such as holoprosencephaly and other birth defects in humans; post-embryonic dysfunction can result in failure of adult tissue regeneration as well as proliferative disorders, such as cancer.|
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