Dr. Evgeny A Budygin

Dr. Evgeny A Budygin
Department of Neurobiology and Anatomy, Wake Forest University School of Medicine
EDUCATION: 1982-1987 I.P. Pavlov Ryazan Medical Institute Ryazan, Russia Pharm. D. 1990-1993 Institute of Pharmacology Russian Academy of Medical Sciences Moscow, Russia Ph.D., Biological Sciences/Pharmacology Advisor: Georgi Kovalev Thesis title: “Effects of nootropic drugs (cognitive enhancers) on dopaminergic transmission in the rat brain” POSTDOCTORAL TRAINING: 1994-1997 Postdoctoral Fellow Department of Institute of Pharmacology Russian Academy of Medical Sciences Advisor: Georgi Kovalev 1997-2000 Postdoctoral Fellow Department of Chemistry The University of North Carolina at Chapel Hill Chapel Hill, North Carolina Advisor: R. Mark Wightman
Research Interest
I am interested in understanding the molecular and cellular processes regulating brain neurotransmission, particularly dopamine and adenosine. I was trained as a classical neurophysiologist and have traditionally used pharmacological approaches combined with microdialysis to probe these systems. In addition, I have pioneered the use of fast-scan cyclic voltammetry in awake and behaving animals, including rats and transgenic mice. This technique allows me to evaluate neurotransmitter dynamics in real-time, so that the particular behavior of the animal can be precisely matched to neurochemical changes. The majority of my career has focused on understanding the plasticity underlying neurotransmitter dynamics in the reinforcing and motivating actions of abused substances, which lead to the development of addiction. My particular emphasis has been on how drugs of abuse induce changes the delicate equilibrium between synaptic processes such as release, reuptake and synthesis of neurotransmitters. However, over the past few years, I have expanded my research program to determining how various behavioral situations impact neurophysiology. In addition, I am combining cutting edge molecular and genetic techniques, including optogenetics and RNA interference, with sophisticated neurochemical approaches to elucidate the molecular mechanisms underlying dopamine neurotransmission. I am also using optogenetic techniques to link neural circuits with behavior in small animals (rats and mice), to allow for analysis of cause and effect relationships.