Dr.Adina-Luminita Milac

Dr.Adina-Luminita Milac Dr.Adina-Luminita Milac
Dr. Milac completed her PhD in Physics, Master’s degree in Biophysics and undergraduate studies in Physics at the Faculty of Physics, University of Bucharest.
 
Biography
Dr. Adina-Luminita Milac is currently main researcher at the Institute of Biochemistry of the Romanian Academy, where she conducts computational biomedical research since 1999. Her research is focused on high-interest high-impact topics such as protein folding and relationship between sequence, structure, dynamics and function of biotechnologically and biomedically important proteins, drug design and cheminformatics. During over 15 years of experience in bioinformatics and computational molecular biochemistry, she authored more than 30 peer-reviewed scientific publications and presented results at more than 40 international scientific meetings, where her presentations were awarded Honorary Mention or Best Poster awards several times. Dr. Milac completed her PhD in Physics, Master’s degree in Biophysics and undergraduate studies in Physics at the Faculty of Physics, University of Bucharest. Research activities during PhD focused on understanding the crucial role of protein glycosylation in protein folding and function, by developing a database of structural information on glycoproteins with experimentally solved structures, in collaboration with Oxford Glycobiology Institute. Doctoral studies in Romania were followed by two postdoctoral training fellowships in computational molecular biology at National Institutes of Health, Bethesda, Maryland, USA. The first two years at NIH were spent in Section on Biological Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases and were dedicated to studying the conformational changes underwent by glycosyltransferases during substrate processing. The next three years were spent in the Laboratory of Cell Biology, National Cancer Institute, on structural modelling and molecular dynamics simulation of ion channels to understand the conformational changes during gating, using an original symmetry-based method to improve structural models accuracy. Once returned at the Institute of Biochemistry in Bucharest, Dr. Milac expanded her contribution to biomedical applications through research in drug design and analysis of structure-activity relationship for pharmacological compounds. In this field, QSAR methods (2D-QSAR, 3D-QSAR-CoMFA, 3D-QSAR-CoMSIA, 3D-QSAR-ALMOND) were extensively applied to antidepressants, antipsychotic, antibiotics and antimicrobial peptides drugs in interaction with membrane receptors and enzymes. Additionally, she developed methods to predict drug binding and affinity, using artificial neural networks. Dr. Milac has also an important editorial activity, as Lead Guest-Editor of a Special Issue of BioMed Research International, as invited reviewer by reputable scientific journals from UK, USA and Romania and as member of the NIH Fellows Editorial Board.
 
Research Interest
Protein structure and function, drug design and cheminformatics, glycobiology, computational molecular biochemistry, bioinformatics and structural biology