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Journal of Clinical Nutrition & Dietetics
ISSN:2472-1921
3 r d W o r l d C o n g r e s s o n
Nutrition, Dietetics
and Nutraceuticals
F e b r u a r y 2 5 - 2 6 , 2 0 1 9
P r a g u e , C z e c h R e p u b l i c
World Nutrition 2019
Growing attempts are being made to rationally utilize systems for human
health improvement and disease prevention. In this context, this
contribution is part of our interest in use nano-encapsulation strategies to
construct nano-vehicles; which in turn will exert the controlled and targeted
delivery of nutraceuticals. A nutraceutical can be defined as the actual
substance that confers a health benefit. Our research group has carried out
the nano-ecapsulation of bioactive compounds as resveratrol (Res), folic
acid (FA), betanin (Bt) into different biocompatible matrices. We also studied
the microvesicle production (MV) by Lactobacillus casei BL23 involved in its
probiotic characterizes the interactions between β-lactoglobulin
(β-lg) and isolated 7S and 11S globulins obtained from defeated soy flour
and folic acid (FA) at different load ratio and their functional implications, in
terms of colloidal behaviour and digestibility. The biological activity of nano-
complexes loaded with FA was explored in terms of their capacity to enhance
the biomass formation of L. casei BL23. The results concerning to nano-
complexes inclusion in culturemedia showed higher bacterial growth. Bt loaded
in a nanovehicle of 11S quinoa seed protein was designed. At this respect, we
found that protein solubility was increased in the presence of Bt. 11S-Bt nano-
complexes showed a synergistic effect in terms of both, antiradical or reducing
power capacity in comparison to Bt as evaluated by to methods, 2,2 -azino-bis-
(3-ethylbenzothiazoline-6-sulfonate) (ABTS), and by ferric reducing antioxidant
power (FRAP). On the other hand, Res was included into nanoparticles of
chitosan, a mucoadhesive and positive charged polysaccharide. Bioactivity
of all these nanoencapsulated materials were evaluated by in-vitro assays
of different human culture cells lines. These nanoencapsulated materials
could have the potentiality to exert the bioactive protection and the controlled
delivery in food, pharmaceutical and nutraceutical products. MV could be used
as nanomachine controlling the host genes expression.
Biography
Oscar E Perez is a Professor at National Lanús University
(Buenos Aires) in the Department of Productive Development
andTechnology.Hehasbeentrained inthefieldofnanoparticles,
biopolymers and food colloids. He has expertise in nano and
microencapsulation of bioactive compound, i.e. bioactives
peptides, micronutrients, folic acid, insulin, growth factors. His
research group has started the study of nanovesicle production
generated by probiotic lactic acid bacteria, the purpose is
exerting the bio-nano-encapsulation of nucleic acids and
reporters overexpressed proteins, the so called inter-kingdom
communication. He is Author and Co-author of more than 50
scientific papers in recognized journals and book chapters. He
has also contributed over 120 communications in conferences.
Nanoecapsulation of nutraceutical compounds and
bionanoencapsulation of proteins and nuclei acids
Oscar E Perez1,2,3 , Rocio Corfield1 , Ana P Domínguez-Rubio1,2 ,
Agustina Alaimo1,2 and Jimena Martinez1,2
1CONICET-Universidad de Buenos Aires, Argentina
2Ciudad Universitaria, Argentina
3Universidad Nacional de Lanús, Argentina
Oscar E Perez et al., J Clin Nutr Diet 2019, Volume: 5
DOI: 10.4172/2472-1921-C1-005