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Journal of Clinical Nutrition & Dietetics
ISSN:2472-1921
3
r d
W o r l d C o n g r e s s o n
Nutrition, Dietetics
and Nutraceuticals
F e b r u a r y 2 5 - 2 6 , 2 0 1 9
P r a g u e , C z e c h R e p u b l i c
World Nutrition 2019
T
here are few studies about the pharmacokinetics of low molecular weight
carotenoids such as crocetin or crocins from saffron (
Crocus sativus
L),
but none of them is performed with a commercial saffron extract. This study
shows the evolution of the main bioactive component, crocin isomers, in blood
of Affron®, a commercial saffron extract, during the pharmacokinetics in
humans after oral administration. Pharmacokinetics was performed collecting
blood samples at different times: 30, 60, 90, 120, 180, 240, 300, 360 minutes
and 24 hours after oral administration of 56 and 84 mg of the commercial
saffron extract to a total of 13 subjects. The analysis of the blood samples was
carried out by high performance liquid chromatography coupled to diode array.
Pharmacokinetics show that crocin isomers are transformed into crocetin
rapidly, since mean time (Tmax) to reach the maximum concentration (Cmax)
of crocetin in blood was between 60 and 90minutes; the Cmax andTmax values
are directly related with the dose administered, being Cmax 0.165 and 0.462
μg/mL respectively. Despite the fact that crocin isomers could be degraded
during digestion, they are able to reach the bloodstream in crocetin form more
quickly than other lipophilic carotenoids of higher molecular weight.
Biography
Paula Almodóvar has received her master’s degree in Food
Science from the Autonomous University of Madrid (Spain)
in 2016. Her degree dissertation consisted on carotenoids
extraction and characterization from
Chlorella vulgaris
. She is
currently pursuing her Master’s degree in Chemical Science
and Technology at The National Distance Education University
(UNED). During her Bachelor´s degree, she collaborated with
research group on bacterial biotechnology (BIOBACT) of the
Institute of Food Science, Technology and Nutrition (ICTAN).
She carried out a research project which was focussed on the
study of genetic variability of
Lactobacillus
related to hydroxy
cinnamic acids metabolism. She has also started working
in Pharmactive Biotech Products S L in May’ 2016, in the
research and development department. Her work is focused
on the method of analyse development and plant extracts
characterization, as well as in scientific production writing. She
has recently published two scientific articles to indexed journals
and participated in different scientific congresses.
palmodovar@pharmactive.euPharmacokinetics of Affron®, commercial saffron
(Crocus
sativus L)
extract
Paula Almodovar
1
, David Briskey
2
, Amanda Rao
3
, Marín
Prodanov
4
and AM Inarejos-Garcia
1
1
Pharmactive Biotech Products S L, Spain
2
The University of Queensland, Australia
3
RDC Global Pty Ltd, Australia
4
CIAL-CSIC and Universidad Autonoma de Madrid, Spain
Paula Almodovar et al., J Clin Nutr Diet 2019, Volume: 5
DOI: 10.4172/2472-1921-C1-005