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Structural Biology 2018
Volume: 4
Biochemistry & Molecular Biology Journal
Page 60
March 15-16 2018
Barcelona, Spain
10th Edition of International Conference on
Structural Biology
T he primary functions of the large intestine (colon) are to
store, process and expel fecal mass residues. These require
sustained motor activity in the organ which is used for the
generation of migrating myoelectrical complexes (MMC) in
order to mix and propel the content. The aim of this research
is to find an effective way to treat patients with constipation or
diarrhea. Themathematical model of a segment of the gut with an
enclosed bolus was constructed. The colon was represented as a
thin deformable soft biological shell with the bolus modeled as a
non-deformable solid sphere. The bolus in motion was subjected
to dry and viscous friction, and the inertia forces were neglected.
The results of simulations of movement patterns resembled
those recorded experimentally and provided quantitative insights
into the spatio-temporal patterns of changes in configuration,
the distribution of contact forces over the bolus, and predicted
the average velocity of colonic transit. Thus, a reciprocal
relationship in the contraction of the longitudinal and circular
smooth muscle was necessary to guarantee the “mixing” type of
movements. Strong conjoint contractions of both muscle layers
were necessary to expel the bolus from the gut. The dynamics
of stress-strain distribution, demonstrated the rise in the intensity
of active propulsive forces in the circular smooth muscle layer
throughout the entire phase of propulsion of the bolus. Viscous,
compared to dry friction had a marked effect on the average
velocity of colon transit. Thus, the addition of osmotic (lactulose,
sorbitol) and rapidly acting lubricant (mineral oil) laxatives,
intraluminally shortened the time required for expulsion of the
bolus significantly. The mathematical model of a segment of
the gut reproduces qualitatively and quantitatively the dynamics
of colonic transit. Viscous and not dry friction is the dominating
parameter in the stability of propulsion.
Computer simulation of colonic propulsive activity
Omar Alqatrawi and R N Miftahof
Arabian Gulf University, Bahrain
Biochem Mol biol J, Volume 4
DOI: 10.21767/2471-8084-C1-009