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E u r o S c i C o n J o i n t E v e n t s o n
Plant Science, Tissue Engineering
and Parasitology
December 03-04 , 2018
Amsterdam, Nether l ands
International Journal of Applied Science - Research and Review
ISSN: 2394-9988
Plant Science | Tissue Engineering | Parasitology 2018
A
biological tissue is a composite material with bottom-up hierarchical structure that is closely related to its heterogeneous
function. The extracellular matrix modulates biochemical and biophysical signalling and its rigidity is an important micro-
environmental parameter that regulates the spatiotemporal dynamics of intercellular signalling. For this reason, many studies
are focused on fabricating scaffolds processed at multiple scales with structural and mechanical properties that are optimal
for eliciting specific response or mimic those found naturally. These scaffolds have to present large surface areas that have
appropriate topology and biochemical cues (e.g, ligands) at the nanoscale for tissue adhesion, while also exhibiting integral
porosity to allow for the exchange of molecules that maintain cellular function. In this talk, the use of amultiscale andmultimaterial
process will be presented to develop 3D
in vitro
model that can mimic the 3D complexity of natural tissue. These novel 3D
in vitro
models can be used for the study of physio-pathological condition and for the analysis of effects on cell activities of different
biomolecule and/or drugs.
g.vozzi@unipi.itMultimaterial and multiscale biofabrication
approach to reproduce the 3D complexity of
natural tissue
Giovanni Vozzi, C De Maria, A De Acutis, A Lapomarda and F
Montemurro
University of Pisa, Italy
Int J Appl Sci Res Rev 2018, Volume: 5
DOI: 10.21767/2394-9988-C2-006