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E u r o S c i C o n J o i n t E v e n t s o n
Plant Science, Tissue Engineering
and Parasitology
December 03-04 , 2018
Amsterdam, Nether l ands
International Journal of Applied Science - Research and Review
ISSN: 2394-9988
Plant Science | Tissue Engineering | Parasitology 2018
C
artilage disease and injury are major health issues: osteoarthritis alone afflicts approximately 8.5 million people in UK.
Regardless the magnitude of the problem, though, clinical success has been limited partly due to the fact that the mechanical
conditions of the tissue
in vivo
do not provide a favourable environment for the regeneration of new cartilage in the defective
site. Consequently, an integer mechanical and biochemical environment should be inserted on the diseased area to stimulate the
growth of the tissue. This could be achieved via the use of a thermosensitive hydrogel that could gel by a change in temperature,
thus giving the possibility of producing the hydrogel under injection, which is a minimal invasive administration. The present study
concentrated on the development and dynamic characterization of a novel hydrogel composed of chitosan and β-glycerophosphate
(β-GP) for the replacement and repair of diseased articular cartilage. The gelling parameters of the composition were optimized
towards improving the hydrogel’s viscosity, while the mechanical properties were evaluated in terms of rheology (viscosity flow
curves and flow behaviour), sensitivity to temperature changes, storage and loss moduli via the use of Anton Paar Physica MCR
301 and TA Instruments DSC Q2000.
s.khaghani@bradford.ac.ukImplementation of chitosan based hydrogel for
cartilage repair
S A Behruz Khaghani
University of Bradford, UK
Int J Appl Sci Res Rev 2018, Volume: 5
DOI: 10.21767/2394-9988-C2-006