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Ann Biol Sci, 2017
ISSN: 2348-1927
August 23-24, 2017 | Toronto, Canada
Annual Conference on
MICROBIAL PATHOGENESIS, INFECTIOUS DISEASE,
ANTIMICROBIALS AND DRUG RESISTANCE
Trend analysis of bacterial uropathogens and their susceptibility pattern: a four-year (2013-2016)
study from Aseer region, Saudi Arabia
Abdulaziz Alamri, Abdulrahman M Alwahhabi, Khalid M Alqahtani, Mohammed S Alqarni, Mohamed E Hamid, Mosleh Abomughaid
and
Muhammad Abid
King Khalid University Medical College, Saudi Arabia
Abdulaziz Alamri et al., Arch Clin Microbiol, 8:5
DOI: 10.4172/1989-8436-C1-003
Objective:
The objective of the study is to analyze the
prevalence and resistance rates of bacterial agents causing
urinary tract infections (UTIs) in Aseer, Saudi Arabia (2013-
2016).
Methods:
This was a four year (2013-2016) retrospective
study undertaken in Aseer Central Hospital (ACH), Saudi
Arabia. A total of 49,779 urine and other UT specimens
obtained from patients suspected of having a UTI were
analyzed. Urine specimens were inoculated onto CLED
agar following standard procedures. Cultures showing
significant bacteriuria were subjected to identification and
sensitivity testing using VITEK 2 system. Data of patients and
uropathogens were assembled, checked and analyzed using
SPSS software.
Results:
Culture positive samples were 49,779 (59.9% males,
40.1% females; p=0.000). Year trend showed significant
variations (p=0.000) and the forecast trend line hypothesized
a clear rise. Age groups 70 to 79 years old were the most
vulnerable group (22.3%). Gram negative bacilli were
91.8% and the major species were
Escherichia coli
(39.7%),
Klebsiella pneumoniae 15.8%, Pseudomonas aeruginosa
13.8%,
Proteus mirabilis
10.6% and
Acinetobacter baumannii
5%. Antimicrobials with high sensitivity rate were linezolid
(99.1%), daptomycin (89.3%), vancomycin (86.7%),
teicoplanin (85.5%), ertapenem (85.1%), fosfomycin (82.1%)
and tigecycline (80.2%). High resistant rates to uropathogens
were encountered with cephalothin (89.8%), nalidixic acid
(86.7%) and ampicillin (81.9%).
Conclusions:
The majority of uropathogens were resistant
to antibiotics commonly used in clinical practice. Linezolid,
daptomycin and vancomycin showed the lowest resistance to
all uropathogens; this can be revised for empirical treatment
of UTIs. Continuous surveillance of uropathogens and their
susceptibility is important
.
Speaker Biography
Abdulaziz Alamri is Professor in King Khalid University Medical College, Saudi
Arabia
e:
aazizamri@gmail.com