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allied
academies
Ann Biol Sci, 2017
ISSN: 2348-1927
August 23-24, 2017 | Toronto, Canada
Annual Conference on
MICROBIAL PATHOGENESIS, INFECTIOUS DISEASE,
ANTIMICROBIALS AND DRUG RESISTANCE
S
taphylococcus aureus
is a major pathogen responsible for
both nosocomial and community-acquired infections. The
severity of
S. aureus
associated infections ranges frombenign
localized skin abscesses to life-threatening diseases, such as
arthritis, osteomyelitis, and endocarditis.
S. aureus
can adapt
rapidly to the selective pressure of antibiotics, and this has
resulted in the emergence and spread of methicillin-resistant
S. aureus
(MRSA). The extensive use and misuse of antibiotics
have created the antibiotic resistance problem. Multi-drug
resistant MRSA may enzymatically degrade the antibiotic,
alter the antibiotic target site, or pump out the incoming
antibiotic from the cell. This leap in the antibiotic resistance
impairs the successful treatment of pathogenic infections.
This progression leads to the fatal outcome and affects the
economic burden of the country. Formation of biofilms by
MRSA is another significant issue to control. It is estimated
that biofilms account for up to 80% of microbial infections
in the body. Biofilms also underlie importunate infections of
implanted medical devices. Within a biofilm, bacteria display
differential gene expression and are upward of 1000-times
more resistant to conventional antibiotic treatment. Bacteria
embedded in biofilms are often difficult to eradicate with
standard antibiotic regimens and inherently resistant to host
immune responses. As a result, treatment of many chronic
S. aureus
biofilm related infections, including endocarditis,
osteomyelitis and indwelling medical device infections is
hindered. Therefore a novel solution must be approached to
curb this growing trend of drug resistance and formation of
biofilms in MRSA. Antimicrobial peptides (AMPs) a growing
class of natural and synthetic peptides, also presents a
broad-spectrum activity. AMPs are small molecules and play
an important role in innate immune system and are effective
against multi-drug resistant organism due to unique mode
of action. Hence, AMPs would be attractive targets against
potential biofilm forming MRSA.
e
:
thenmozhirr@gmail.comEffect of antimicrobial peptides against methicillin resistant
Staphylococcus aureus
isolates
Thenmozhi Ramalingam
and
Thajuddin Nooruddin
Bharathidasan University, India
Arch Clin Microbiol, 8:5
DOI: 10.4172/1989-8436-C1-003