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Ann Biol Sci, 2017
ISSN: 2348-1927
August 23-24, 2017 | Toronto, Canada
Annual Conference on
MICROBIAL PATHOGENESIS, INFECTIOUS DISEASE,
ANTIMICROBIALS AND DRUG RESISTANCE
S
taphylococcus aureus
and related bacteria such as
Streptococci
cause Millions of fatal human infections
annually around the globe with sequelae of complications
and of which some are very difficult to treat with cheap and
widely available antibacterial drugs especially in Uganda,
East Africa. There is also an increasing incidence of bacterial
resistance against various categories of antibacterial drugs
causing chronicity of some infections. The following are the
examples of virulence factors; lipases, collagenases, super
antigens, exfoliatin A and B, haemolytic toxins e.g. beta
toxin which is a sphingomyelinase and protein A. The major
will be in; Osteomyelitis, toxic shock syndrome, sepsis and
necrotizing fasciitis. The purpose of this study is to analyze
these virulence factors in detail which will subsequently lead
to the discovery (innovation) of polyvalent antitoxins (e.g.
in vaccine form or a gamma globulins) that will be used to
prevent such fatal infections in groups at high risk. The study
will also reduce future antibiotic abuse and eventually also
reduce antibiotic resistance.
e:
robirakiza@gmail.comThe role of
Staphylococcus aureus
, related bacteria and their virulence factors in pathogenesis of
multi organ infections: Future molecular targets in prevention and treatment, in addition to already
available antibacterial drugs
Manirakiza Robert
Gulu University, Uganda
Arch Clin Microbiol, 8:5
DOI: 10.4172/1989-8436-C1-003