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Page 81
allied
academies
Ann Biol Sci, 2017
ISSN: 2348-1927
August 23-24, 2017 | Toronto, Canada
Annual Conference on
MICROBIAL PATHOGENESIS, INFECTIOUS DISEASE,
ANTIMICROBIALS AND DRUG RESISTANCE
Background:
Different delivery modes may affect the
susceptibility to allergic diseases. It is still unknown whether
early intervention with probiotics would counteract this
effect.
Objectives:
The effect of different delivery modes on
immune status and nasal symptoms was investigated on
established allergic rhinitis (AR) mouse model. In addition,
the immunoregulatory effects and mechanisms of different
feeding manners with
Bifidobacterium breve (B. breve)
were
examined.
Methods:
Live lyophilized
B. breve
was orally administered
to BALB/c mice born via vaginal delivery(VD) or cesarean
delivery (CD) for 8 consecutive weeks, after which they were
sensitized by ovalbumin (OVA) to establish experimental AR.
Nasal symptoms, serum immunoglobulins, cytokines, splenic
percentages of CD4+ CD25+ Foxp3+ regulatory T(Treg) cells
and nasal eosinophil infiltration were evaluated.
Results:
Compared with VD mice, mice delivered via
CD demonstrated more serious nasal symptoms, higher
concentrations of OVA-specific immunoglobulin (Ig) E, more
nasal eosinophils and lower percentages of splenic CD4+
CD25+ Foxp3+ Treg cells after establishing experimental AR.
These parameters were reversed by administering
B. breve
shortly after birth. However, the effect of
B. breve
did not
differ between different delivery modes.
Conclusion:
CD aggravates the nasal symptoms of AR
mice compared to VD. This is the first report that oral
administration of
B. breve
shortly after birth can significantly
alleviate the symptoms of AR mice born via both deliveries,
probably via activation of the regulatory capacity of CD4+
CD25+ Foxp3+ Treg cells.
e:
672092965@qq.comEffects of
Bifidobacterium
breve feeding strategy and delivery modes on experimental allergic rhinitis
mice
Jian-jun Ren
1
, Yu Zhao
1
, Feng-Ling Yang
1
, Dan LV
1
, Shi Hung
1
, Jie Zhang
1
, Ping Lin
1
, Shi-Xi Liu
1
, Nan Zhang
2
and
Claus Bachert
2
1
Sichuan University, China
2
Ghent University, Belgium
Arch Clin Microbiol, 8:5
DOI: 10.4172/1989-8436-C1-003