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allied
academies
Ann Biol Sci, 2017
ISSN: 2348-1927
August 23-24, 2017 | Toronto, Canada
Annual Conference on
MICROBIAL PATHOGENESIS, INFECTIOUS DISEASE,
ANTIMICROBIALS AND DRUG RESISTANCE
Background & Objective:
The side effects of NSAIDS drugs
have caused increasing interest of scientists in herbal
medicines as alternative treatment. In this study, the anti-
inflammatoryeffect of seedand fruit of datepalmhydroalcolic
extracts, due to having antioxidants, was studied.
Materials & Methods:
In this study, the extracts of date
palm seed and fruit were prepared by maceration method
in 70% alcohol. Eighty (80) male rats Wistar, divided into
10 groups of eight (8) in each, 4 groups received different
doses (100, 200, 400 and 600 mg/kg) of seed extract and
4 other groups different doses (100, 200, 400 and 600 mg/
kg) of fruits extract of the palm and the positive control
aspirin (300 mg/kg) and the negative control group saline
(5 ml/kg) via injection intraperitoneally. Half an hour later
all animals received 100 µl of 1% carrageenan into the rats’
hind paw subcutaneous. The changes in rats paw edema was
measured by plethysmometer every hour for five hours.
Results:
The effect of all of the doses of date palm seed
extract on edema were less than Aspirin (P<0.05). But
there was no significant difference between the group that
received 400 and 600 mg/kg date palm fruit extract when
compared with aspirin group. The dose 400 mg/kg of fruit
extract showed the most anti-inflammatory effect and it was
assigned as the best dose.
Conclusion:
It is likely that with further studies on different
model of animals and also on human model the palm fruit
extract could be used for pain treatment.
e
:
siavash.farma@gmail.comThe preventive effect of date palm (
Phoenix dactylifera
) seed and fruit hydroalcoholic extracts on
Carrageenan-induced inflammation in male rat’s hind paw
Ardeshir Arzi, Siavash Azarbani, Hanieh Zarringhalam, Zahra Nazari
and
Mohsen Rezaei
Jondishapour University of Medical Sciense, Iran
Arch Clin Microbiol, 8:5
DOI: 10.4172/1989-8436-C1-003