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Endocrinology 2018 Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432 Page 53
August 09-10, 2018
Madrid, Spain
11th International Conference on
Endocrinology and
Diabetology
Several studies highlight curcumin’s benefit as a hypoglycemic
agent, however; a limited number of reports present the
importance of curcumin in improvement of pancreatic islets in
diabetes. The antidiabetic effect of a novel curcumin derivative
and its effect on pancreatic islet regeneration in experimental type
I diabetes were investigated. Streptozotocin-diabetic rats were
treatedorallywith thenovel curcuminderivative (NCD) for 40days.
Fasting plasma glucose, insulin and C-peptide were determined
periodically for 10 months. Histopathology was performed to
allow the assessment of pancreatic islet morphology. Insulin
and CD105 were detected immunohistochemically. NCD treated
diabetic rats showed significantly lowered plasma glucose and
increased plasma insulin and C-peptide levels. Plasma insulin and
C-peptide continued to increase for ten months reaching levels
significantly higher than the basal level. NCD treated rats showed
the appearance of primitive cell collections, large insulin positive
cells and CD105 positive cells in the adipose tissue infiltrating the
pancreatic tissues. This was followed by the gradual appearance
of insulin positive cells in the islets while, CD 105 positive cells
remained in the adipose tissue. After 5 and up 10months from the
onset of diabetes, treated rat pancreas showed, well developed
larger sized islets with disappearance of primitive cell collections
and CD 105 positive cells. The NCD possesses antidiabetic
actions and enhanced pancreatic islets regeneration properties.
The effect of a novel curcumin derivative on pancreatic islet
regeneration in experimental type-1 diabetes in rats: long term
study
Ameen M Rezq1 , Mohamed T Abdel Aziz1, Mohamed F El Asmar2, Soheir M
Mahfouz1, Mohamed A Wassef1, Hanan H Fouad1, Hanan H Ahmed1 and Fatma M Taha1
1Cairo University, Egypt
2Ain Shams University, Egypt
J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C2-006