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Endocrinology 2018
THE AIM OF THE STUDY
was to assess the parameters of ovarian reserve in patients with chronic kidney disease stages 3-4 and
compare them between 3 groups of patients with decreased GFR
MATERIALS AND METHODS:
The examination included 24 patients ages 23 to 45, all with chronic kidney disease stages 3-4.
The examined parameters of ovarian reserve included: transvaginal ultrasonography (to assess AFC and ovarian volume), serum AMH,
FSH and E
2
assessed in early follicular phase of menstrual cycle.
All patients included to the study had been diagnosed with CKD (kidney damage or dysfunction) and had decreased GFR below 60
ml/min/1.73 m
2
for at least 3 months.
Patients were divided depending on the glomerular filtration rates into 3 groups:
•
with GFR 45-59 ml/min/1,73 m
2
•
with GFR 30-44 ml/min/1,73 m
2
•
with GFR 15-29 ml/min/1,73 m
2
RESULTS:
Parameters of ovarian reserve: ovarian volume, AFC, AMH, FSH; estradiol (E2) depending on estimated glomerular filtration rates
(eGFR) ranges in patients with CKD
Parameter of ovarian reserve
GFR 45- 59 (mL/min/1.73 m
2
)
GFR 30- 44 (mL/min/1.73 m
2
) GFR 15- 29 (mL/min/1.73 m
2
)
P
x ± SD
M
e
x ± SD
M
e
x ±
SD
M
e
Ovarian
volume
Right ovary
(cm3)
3.85± 2.14
3.55
3.49±0.63
3.60
2.68± 0.30
2.74
0.476
Left ovary
(cm3)
4.51± 3.07
3.70
2.87±1.12
2.73
2.20± 0.58
2.35
0.208
Antral
follicle count
(AFC)
Right ovary (n)
4.06±1.44
4.00
4.00±1.73
3.0
3.33± 1.53
3.00
0.698
Left ovary (n)
4.00±1.55
4.00
3.60±0.55
4.0
2.00±1.00
2.00
0.099
AMH (ng/mL)
1.40± 0.65
1.52
1.07±0.65
1.09
0.63±0.43
0.63
0.189
FSH (IU/L)
8.42± 4.06
7.52
8.27±1.23
8.47
6.71± 1.47
7.39
0.593
E2 (pg/mL)
81.98±59.15
65.15
151.03±175.54
88.0
149.81±59.78
139.20
0.135
CONCLUSION:
There are no significant differences in parameters of ovarian reserve: ovarian volume, AFC, AMH, FSH and E2 among the
patients in stage 3 or 4 of chronic kidney disease.
Parameters of ovarian reserve in patients with chronic kidney disease
depending on glomerular filtration rates.
Iwona Szydłowska, Aleksandra Marciniak, Agnieszka Brodowska, Marcin Lisak, Sylwia Przysiecka,
Jacek Różański.