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Endocrinology 2018
Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432
Page 43
August 09-10, 2018
Madrid, Spain
11
th
International Conference on
Endocrinology and
Diabetology
M
itochondrial dysfunctionmay play a key role in the progression
of steatosis to nonalcoholic steatohepatitis (NASH); however,
the molecular mechanism that controls the structure and function
of mitochondria in NASH is not clearly understood. Here, we
demonstrated that RORα is a regulator of expression of BNIP3
and PGC-1α, and thereby enhances mitochondrial quality. First, we
observed that liver-specific RORα knockout mice (RORα-LKO) were
more susceptible to high-fat diet-induced NASH compared with
control, probably due to mitochondrial dysfunction. Concordantly,
mitochondrial fission in response to nutrient stimuli was abolished
with downregulation of BNIP3 and Phospho-DRP1 in the
hepatocytes of RORα-LKO. RORα enhanced oxygen consumption
rate and expression of genes associated with mitochondrial
quality control. Finally, we observed the positive correlation of
the expression levels of BNIP3 and PGC-1α with those of RORα
in patients with steatohepatitis. Together, we demonstrated that
RORα mediates mitochondrial quality under nutrient-overloaded
conditions and propose RORα as a potential therapeutic target in
treatment of NASH.
Biography
Mi Ock Lee received her undergraduate and Master’s Degree in Pharmacy
from Seoul National University (SNU), Republic of South Korea; pursued PhD
in Pharmacology from University of Minnesota, USA. She is presently working
as a Professor at the SNU- College of Pharmacy. She worked as a Postdoctoral
Researcher at Sanford BurnhamPrebys Medical Discovery Institute, SanDiego
(USA). She also worked as an Assistant Professor at the Yonsei University Col-
lege of Medicine, Republic of South Korea.
molee@snu.ac.krLiver-specific deletion of ROR
α
aggravates diet-induced
nonalcoholic steatohepatitis by inducing mitochondrial
dysfunction
Mi Ock Lee, Hyeon Ji Kim, Yong Hyun Han, Hyelin Na
and
Ju Yeon Kim
Seoul National University, Gwanak, Republic of South Korea
Mi Ock Lee et al., J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C2-006