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Endocrinology 2018
Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432
Page 42
August 09-10, 2018
Madrid, Spain
11
th
International Conference on
Endocrinology and
Diabetology
Background:
It is familiar that 80%of the iodineentry into the thyroid
gland is in the phenol ring of thyroid hormones. The density of the
thyroid gland in Hounsfield unit (HU), determined by computed
tomography (CT), is directly proportional to the concentration of
intrathyroid stable iodine. Hence, the thyroid density index in HU
reflects the level of hormone formation and the preserved iodinated
thyroid hormones directly in the thyroid gland. The thyroid gland
is the only endocrine organ that, after the synthesis of hormones,
stores them up to 50 days in the thyroid structure and secretes
hormones into the blood at the request of the body.
Aim:
The purpose of this work is to study the level of intrathyroidal
hormone in clinical manifestations of thyroid gland diseases using
diagnostic method of computed tomography.
Materials & Methods:
The study comprised 160 individuals, aged
45±6.8 years, with thyroid gland diseases, which are accompanied
with functional impairment of thyroid gland. Individuals with
hypothyroidism included 87 patients - group 1, 59 individuals with
primaryhypothyroidism(group1a)including-18withiodine-induced
hypothyroidism (group 1b). 35 individuals with hyperthyroidism -
group 2 (including 8 with iodine-induced hyperthyroidism (group
2a), 36 individuals with euthyroidism - control group. All individuals
were examined clinically and laboratory with determination of
hormones–TSHand fr.T4.The study of thecontent of intrathyroidal
iodine was carried out using computed tomography (CT) on the
apparatus “Symbia T16” (Siemens) with determination of thyroid
density in units of Hounsfield (HU). For the standard level, the
values of HU 85-140 units were taken.
Results:
In individuals with iodine-induced hyperthyroidism (group
2a), the density in HU was significantly increased to 182±12, and
the TSH level was 0.03±0.01 mU/ml. In group 1 – HU was 85±9.0,
and the level of TSH 0.04±0.01 mU/ml. In the group of individuals
with hypothyroidism, the level of HU values also had a noticeable
difference. In a subgroup of individuals with iodine-induced
hypothyroidism (group 1b), the content of intrathyroidal iodine was
above the reference values of 181±6 at a TSH of 6.0±0.9 mU / ml,
and in group 1a (primary hypothyroidism) –HUwas 53±7.0, and the
TSH level was 9.28± 2.7 mU/ml. In the control group, the reported
indicators were within reference values. Our studies showed that
in all cases when there was an iodine-induced impairment of the
thyroid function, the density in HU was above 140.
Conclusions:
Contemporary assessment of thyroid density in
HU with CT and TSH level in the bloodstream allows differential
diagnosis between iodine-induced and true thyroid dysfunction,
as well as correction for the error in determination of TSH
concentration as a result of the influence of non thyroidal factors.
Assessment of thyroid densities in HU in CT should be used for
screening the risk of thyroid dysfunction and for determining the
need for iodine prophylaxis and monitoring its effectiveness with
a view to preventing iodine-induced transient thyroid dysfunction.
Biography
Ramchandra Sargar has completed his graduation (MBBS) from Smolensk
State Medical University, Russia and clinical residency from RUDN University.
Currently He is doing scientific research (PhD) from same university, (RUDN
University). He has published the articles not only in Russian journals (Web of
Science) but also in International Journals (Scopus). Area of research interest
is early diagnosis of thyroid gland diseases.
Rama.sargar@gmail.comIntrathyroidal iodine content and streaming features of
thyroid gland diseases
Ramchandra Sargar
1
, Kurnikova I.A
1
, Tomashevskiy I.O
2
and
Skarbkova H S
3
1
RUDN University, Russia
2
Central clinical hospital №2 named after N.A. Semashko, Russia
3
Belarussian State University, Belarus
Ramchandra Sargar et al., J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C2-006