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Endocrinology 2018 Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432 Page 61
August 09-10, 2018
Madrid, Spain
11th International Conference on
Endocrinology and
Diabetology
Introduction: Type 1 diabetes (T1DM) is associated with
increased risk of cardiovascular disease. Several studies have
highlighted the metabolic syndrome and IR (insulin resistance) as
an important precursor of cardiovascular disease, however, few
data exist on its occurrence in type-1 diabetes.
Objectives: The objective of this work is to study the presence
of early signs of atherosclerosis as well as myocardial structure
and function in relation to some predisposing risk factors for
cardiovascular disease as metabolic syndrome and estimated
glucose disposal rate (eGDR) as, a surrogate measure of insulin
resistance, in T1DM patients.
Study Design & Methodology: This study was conducted on 30
T1 diabetic patients, age range 11-30 years and having history
of diabetes 5 years. They were compared to apparently healthy
subjects aged around 20. After complete clinical examination
including body mass index (BMI), waist circumference (WC),
waist-hip ratio(WHR) and blood pressure measurements, blood
samples were withdrawn to determine fasting, and postprandial
blood glucose levels, HbA1c, lipid profile, fasting C-peptide, 24-h
urinary albumin and fundus examination. Estimated glucose
disposal rate (eGDR) was calculated and used as a marker of
IR. Of imaging techniques, echocardiography and carotid intima
media thickness (CIMT) were done.
Results: There was significant difference between patients and
controls regarding blood glucose, HbA1c, lipid profile and WHR.
Diabetic patients had significant lower HDL, C- peptide, and
higher TG, 24 h micro-albuminuria, and CIMT, in comparison to
control subjects. Metabolic syndrome criteria were met in 26.7%
of patients. Cut off value of eGDR was <9 (mg/Kg-1.min-1), with
sensitivity of 70% and specificity of 100%. Twenty one patients
(70%) had eGDR <9 (mg/Kg-1.min-1), and 9 patients (30%) had
eGDR >9 (mg/Kg-1.min-1). Also there were negative correlation
between eGDR and HbA1c, WHR, CIMT, interventricular septal
thickness(IVST), posterior wall thickness (PWT), and left
ventricular mass index (LVMI).
Conclusion: Main cardiovascular risk factors are visceral obesity,
bad glycemic control and increased CIMT. Metabolic syndrome is
estimated to affect 26.7% of T1D patients. eGDR is a reliable tool
to pick up patients with IR with sensitivity of 70% and specificity
of 100%. Although T1DM patients have low C- peptide level, yet
70% of them are IR.
Cardiovascular risk factors and subclinical atherosclerosis in
Egyptian patients with T1DM
Zeinab A. Hasan
Girls-Al Azhar University, Egypt
J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C2-006