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Endocrinology 2018
Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432
Page 57
August 09-10, 2018
Madrid, Spain
11
th
International Conference on
Endocrinology and
Diabetology
Background & Aim:
Genital anomalies including disorders of
sexual development (DSDs) are prevalent in all societies. There is
no study on DSDs in Ghana. We aimed to describe characteristics
of abnormal genitalia and prevalence of DSDs in neonates
delivered at Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Methods:
Trained research assistants performed systematic
genital examination in consecutive neonates over one year.
All neonates with suspected abnormal genitalia were further
examined by pediatric endocrinologists. Informed consent was
obtained for all participants.
Results:
A total of 10337 neonates (including 389 stillbirths)
were delivered. We examined 9255 neonates (93% of all live
births) within 72 hours of life. Normal genitalia were identified
in 47.93% females and 51.86% males. Nineteen neonates
(0.21%) had disorders of sexual disorders (DSDs). Seven had
ambiguous genitalia (four with clitoromegaly, presence of uterus
on ultrasound and elevated 17-hydoxyprogesterone, suggesting
CAH (Congenital adrenal hyperplasia). The remaining three had
microphallus, gonads in bifid scrotum or in the inguinal region,
suggesting male DSDs. The twelve other neonates had isolated
micropenis (n=5) and isolated hypospadias (n=7) and were
considered as males.
Conclusions:
DSDs including CAH is not uncommon in Ghana and
proper access to diagnostic tools and medicines is important.
Recommendation:
All babies in low income countries should
have genital examination at birth so as to identify DSDs and subtle
anomalies of genitalia at birth.
ekameyaw@yahoo.comPrevalence of disorders of sexual development in neonates in
Ghana
Emmanuel Ameyaw
Kwame Nkrumah University of Science and Technology, Ghana
J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C2-006