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Endocrinology 2018 Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432 Page 44
August 09-10, 2018
Madrid, Spain
11th International Conference on
Endocrinology and
Diabetology
Purpose: The purpose of this work is to study the features of
laboratory indicators in patients with type 2 diabetes who received
insulin therapy depending on the insulin dose.
Methods & Materials: Seventy three patients of both sexes were
examined and treated in the endocrinology department of the
municipal clinical hospital. Patients age ranged- 45 to 70 years
old. Depending on the dose of insulin (within physiological need
or higher) patients were divided into 2 groups. Patients in the first
group (45 people) were treated with insulin dose ≤40 U/day; the
second group (28 people) received insulin >40 U/day. During the
exam-ination of patients, special attention was paid to study the
following parameters: the current age of the patient and the age
at the beginning of the disease, duration of type 2 diabetes, body
mass index (BMI). The determination of fasting and postprandial
glycemia, glycated hemoglobin (HbA1c) were included in glycemic
control. Laboratory parameters like choles-terol, high-density
lipoproteins (HDL), low-density lipoproteins (LDL), very-low-density
lip-oproteins (VLDL), triglycerides, atherogenic index, crude
protein, level of creatinine and urea, transaminases; insulin level
and C-peptide have been analyzed.
Results: Parameters of the average age of patients in both groups
hadslight difference (61.2±3.9and62.3±4.5years), at thebeginning
of the manifestation of type 2 diabetes, pa-tients from second
group (48±4.4 years) were significantly younger than patients of
the first group – 54.6±2.1 years. Patients in second group were
more likely to have obese (BMI=34.8±3.2 kg/m2) than patients
in first group (BMI=28.8±2.8 kg/m2), which partially explains the
higher need for exogenous insulin. No significant differences
were found be-tween groups according to the daily glycemic
control criteria. Patients in group 1 had higher rates of pre-prandial
glycemia than in group 2 – postprandial glycemia. Level of НbА1с
in patients of the first group is – 8.23±0.6%, in second group is –
9.92±0.4%. There were no significant differences inmean values of
patients of different groups in the structure of lipid profile. Patients
of the second group, in which tendency to enhanced atherogenic
index has been observed. The values of cholesterol-HDL, VLDL
and triglycerides were higher in pa-tients with a total daily dose
of insulin ≤40 U/day. Remnant of insulin secretion remained un-
changed in both groups. C-peptide level in group 1 was 1.41±0.13,
was 0.93±0.21 ng/ml in second group (at reference values 0.78-
1.89 ng/ml). The correlation (Spearman Rank Order Correlations)
of the HbA1c index with the C-peptide level was more significant
(r=-0.39, p<0.01) than the correlation of this indicator with the dose
of insulin (r=-0.17, p<0.05).
Conclusion: The risk factors of secondary insulin resistance in
patients with type 2 diabetes include: the duration of the disease
more than 10 years, BMI over 34 kg/m2 and the age to the
manifestation of diabetes below 50 years.
Biography
Garoyan Vera Ogannesovna a 6th year student of RUDN-university, Moscow,
Russia. Papers published: “Clinical Gerontology” ISSN: 1607-2499 AORTIC
VALVE STENOSIS IN PA-TIENTS OF ELDERLY AND SENILE AGE. Area of re-
search interest: Endocrinology and Cardiology.
Metabolic changes in patients with type 2 diabetes and
secondary insulin resistance
Garoyan V and Temnenko N
RUDN University, Russia
Garoyan V et al., J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C2-006