Background: Nanocarriers of different materials are being developed to improve their efficacy in various current treatments. We propose to use xylitol to establish a novel nano-immunotherapy administered sublingually to bring the different molecular compounds directly in contact with the immune cells located in the oropharyngeal mucosa. The ultra-low doses allow to avoid any side effects and to have a very regulatory impact on various signaling pathways in the cell. This is of course also valid for viruses, where genes and molecules responsible for their virulence can also be the subject of the same type of regulation. This manuscript presents a case of a close relationship between a chronic inflammatory rheumatism, in this case ankylosing spondylitis, and a virus of the Parvoviridae family, the well-known Parvovirus B19.
Methods and Findings: To reach our objective of immunogenetic regulation, we act first at the epigenetic level by introducing microRNAs in our formulas, in order to use their formidable post-transcriptional regulatory potential. In application of the rules of Hormesis, the ultra-low doses used in our formulas will allow a fine tuning of the post-transcriptional regulatory action of micro-RNAs, and thus promote a true modulation of the corresponding gene expression. As in the description of the clinical case, the approach of the BI(G)MED is holistic i.e. globalizing, seeking to identify the various actors involved in the development of a chronic disease, starting of course with different types of well-known microorganisms. This therapeutic approach obviously requires a very rigorous preliminary diagnostic procedure, which will allow to support the treatment with precise biological data. Thus, in the clinical case presented, the demonstration of a reactivation of parvovirus B19 and the neutralization of the latter by an appropriate therapy has made it possible to stabilize the evolution of a formidable chronic disease and to significantly improve its medium-term prognosis.
Conclusions: The description of this clinical case makes it possible to highlight not only the density of the interactive processes taking place in our cells, but also their tremendous potential for self-regulation, provided that the latter is the subject of an appropriate therapeutic approach i.e. biomimetic. This is the condition to ensure the return to an effective cellular homeostasis.