In vitro anti-inflammatory, analgesic and acute toxicity studies of ethanol extracts of Andrographis paniculata Nees and Spilanthus acemella Murr

The present study was carried out to evaluate the anti-inflammatory, analgesic and acute toxicity effects of Andrographis paniculata Nees and Spilanthus acemella Murr crude ethanolic extracts. The antiinflammatory activity was measured by carrageenan induced rat paw edema and analgesic activity was measured by acetic acid writhing test methods. 300mg/kg of S. acemella extract shown significant (p<0.05) antiinflammatory while 300mg/kg A. paniculata extract shown significant (p<0.05) analgesic activity as compared to diclofenac sodium. The ethanolic extracted has shown no toxic effect upto 1500 mg/kg body weight of Wister male rats. The results were obtained in a dose dependent manner. It may be concluded that the ethanolic extract of Andrographis paniculata Nees and Spilanthus acemella Murr has antiinflammatory and analgesic potential and have no toxic effect may be used as a future herbal medicine.

Author(s): Babeet Singh Tanwer, Soniya Choudhary and Rekha Vijayvergia

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