Formulation and evaluation of Ciprofloxacin hydrochloride dispersible tablets using natural substances as disintegrates

Dispersible tablets of Ciprofloxacin hydrochloride were prepared using natural substances as disintegrate such as Isabgol husk powder, alginic acid and agar powder in different concentration by direct compression method. Formulations were evaluated for the standard of dispersible tablets and were compared among themselves. Dispersible tablets of Ciprofloxacin hydrochloride were prepared using direct compression method after incorporating different natural disintegrates. The various formulations were evaluated for hardness, weight variation, friability, disintegration time, In vitro disintegration time, uniformity of dispersion, drug content/content uniformity, and dissolution study as per official standards. It was observed that all the formulations were acceptable with reasonable limits of standard required for dispersible tablets. The study reveals that natural gums used as disintegrates were effective and isabgol at a concentration of 5% produce best dispersible effects.

Author(s): Setia Anupama, Goyal Naveen and Kansal Sahil

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