Evaluation of Cardioprotective Activity of Magnolia officinalis Bark Extract against Doxorubicin Induced Toxicity in Mice

This study investigated the cardioprotective effects of Magnolia officinalis bark extract in C57 mice. The extract's ability to protect against doxorubicin (3 mg/kg, i.p.) induced cardiotoxicity was evaluated. Body weight, heart weight index, LDH and CK-MB levels were measured as markers of cardio protection. Histopathological analysis of heart tissues was also performed. The Magnolia officinalis extract contained various bioactive compounds, including cardiac glycosides, carbohydrates, proteins, alkaloids, glycosides, saponins and phenols. The extract effectively protected the hearts of mice from doxorubicin-induced cardiotoxicity. Histopathological examinations supported the biochemical findings. The extract's cardioprotective action is likely attributed to its antioxidant properties. The Magnolia officinalis bark extract possesses cardioprotective activity when tested in C57 mice.

Author(s): Sidhant Sharma* and Rajdeep Kaur

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