Cyclocondensation, Characterization and Antibacterial Activities of Novel 5-Chloro-1HIndole-2,3-Dione Derivatives

In our ongoing research to identify effective and simple compounds, we studied the cyclocondensation of 5-Chlorosatin derivatives by the action of Diamino-5- bromo-pyridine to give heterocyclic possessing Pyrido [2,3-b] Pyrazines, in a moderate to good yield. The synthesized products were characterized by 1H NMR and 13C NMR. In addition, the antibacterial properties in vitro were tested against certain microorganisms using the disk diffusion technique. The final results revealed that the majority of the compounds exhibited good antibacterial activity against Bacillus cereus and Staphylococcus aureus.

Author(s): Z Tribak, MK Skalli, A Haoudi, Y Kandri Rodi, O Senhaji and EM Essassi

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