Antitumor performance regulation of drug-conjugated gold nanoparticles: Structure-efficacy relationship studies

Drug-conjugated nanoparticle is a uniquely structured drug delivery system. In each conjugate, the nanoparticle acts as a core to crosslink more than 100 prodrug molecules and prodrug is composed of its parent drug molecules covalently connected on the surface of nanoparticles via proper spacers. This system can be seen the assembly of prodrugs in the nanoscale and show the advantages of both prodrug and nanoparticles. In comparison with conventional therapies, nanomedicine shows prominent clinical performance, with better therapeutic efficacy and less off-target toxicity. As an important component of nanomedicine, gold nanoparticle (GNP)-based nanodrugs have attracted considerable interest because of their excellent performance given by the unique structure.

Author(s): Ya Ding

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