A Rare Case Report of Cerebral Amyloid Angiopathy Related Inflammation Presenting as Acute Aphasia

Cerebral Amyloid Angiopathy Related Inflammation (CAARI) is a form of reversible encephalopathy presenting with acute or subacute onset of behavioural changes, seizures, and decline in cognition or neurological deficits. It is generally seen in adults in their 5th or 6th decade. The etiopathogenesis of caari is very closely related to alzhemiers disease which is due to deposition of amyloid precursor protein in perivascular area and thus causing cererbal edema. It can mimic a number of conditions like encephalitis, neuroproliferative disorder or vasculitis. Proper clinical assessment with aid of radiological tools helps to recognise this reversible condition early and thus providing prompt management and early recovery. Caari rarely presents with symptom like acute aphasia Here by we describe a 77 year old female on treatment for alzehmeirs disease presenting with acute aphasia and behavioural changes who was diagnosed clinically and radiologically as CAARI and treated with adequate immunosuppressive therapy and thereby early improvement and resolution of symptoms. Followup MRI after 6 months showed disappearance of periventricular inflammatory changes thus confirming the diagnosis.

Author(s): Urvi Khambhati*

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