Medicinal plants still play a vital role in the primary healthcare of this local communityThe present study deals with comprehensive ethnobotanical survey of the traditional uses of plants in Nawarangpur district, Odisha,India.Data was collected through field assessments from traditional healers and locals by means of personal interviews and semi-structured questionnaires. Voucher specimens were collected following standard methods, identified with the help of pertinent floras and taxonomic experts and deposited in the Herbarium, RRL-B, India for future references.A total of 51 plants belonging to 35 families were recorded out of which major life forms were in the order of herbs, trees, shrubs and climbers. The leaf parts were widely used followed by root, bark, whole plant, seed, fruit, rhizome, petiole and latex. Traditional medicines also have the potential to form the basis of pharmaceutical drugs for the treatment of a range of diseases. Further, the information requires validation for further clinical usage.